MEDICINE

NCI Grants Awarded to IHVs to Prevent Cancer and Improve Screening in Sub-Saharan Africa

Newswise — Researchers at the Institute of Human Virology (IHV) at the University of Maryland School of Medicine (UMSOM) receive two five-year awards totaling $7.5 million from the National Cancer Institute (NCI) at the National Institutes of Health Did. One of the awards aims to reduce the incidence of lung and other cancers associated with tobacco use in Botswana. The other focuses on improving screening and treatment of anal precancer in Nigeria. Both grants will leverage existing HIV treatment and prevention infrastructure in low- and middle-income countries to reach people living with HIV who are most at risk for these specific types of cancer.

“With the growing cancer burden among people living with HIV in sub-Saharan Africa and the disproportionate disproportion of most cancer research to high-income countries, the world needs to focus on prevention and treatment in these regions. It is important to advance comprehensive cancer research, which will contribute globally to the fight against cancer among people living with HIV.” Said Robert C. Gallo, M.D.Homer & Martha Gudelsky Distinguished Professor of Medicine, Co-Founder and Director of IHV at UMSOM, Co-Founder and Chair of the Scientific Leadership Board of the Global Virus Network (GVN).

Botswana Lung Cancer Study

Botswana’s smoking cessation enhancement trial B SMART, screening patients for smoking across a network of HIV treatment facilities. Provide simple interventions using the 5 A’s: Ask, Advise, Assess, Help and Arrange for pharmacotherapy to help patients quit smoking. Quitting smoking is the most effective way to prevent smoking-related cancers.

“Smokers with HIV have a significantly increased risk of several tobacco-related cancers,” he said. B SMART study Dr. Mann Sharrat, MHS, Professor of Medicine, Director of the Center for Global Health, Education and Biosecurity (Ciheb) of the IHV of UMSOM and Director of Global Health Sciences of the Department of Epidemiology and Public Health of UMSOM. ” B SMART This study uses implementation science to enact a comprehensive public health strategy embedded in real-world care systems. Until now, patients have been frustratingly left behind. ”

Botswana has the highest rates of HIV and tobacco use in sub-Saharan Africa. Lung cancer is the most common non-AIDS-caused cancer among people living with HIV, accounting for 20% of his cancer burden.of B SMART The research in Botswana is poised to support the Botswana government’s national goals on smoking cessation among citizens.

Nigerian Anal Cancer Study

of influence The study, which stands for Integrated Model for Prevention of Anal Cancer Using HSIL (High-Grade Intraepithelial Lesion, also known as Precancer) Screening and Treatment, aims to screen for and treat precancer. , prevent anal cancer in sexual and gender minorities. Sex with other men and transgender people. The study will be conducted at his TRUST clinic in Nigeria, established by his IHV in 2012.

Human papillomavirus (HPV), the virus that causes anal cancer, is transmitted through anal sex. Because HIV-infected individuals may have suppressed immune systems, HPV-infected individuals may experience persistent, high-risk infections and develop precancerous conditions that may progress to cancer. more likely to. Following successful cervical cancer prevention strategies, health care providers have recently learned that precancers can be treated to prevent anal cancer.of influence This research aims to immediately transfer knowledge from research to practice in low- to middle-income settings.

“Because it is very difficult in Nigeria to identify men who have sex with other men for fear of being imprisoned or socially ostracized, HPV-related diseases are usually widespread before they are identified. will reach.” Said influence principal investigator Dr. Rebecca NowakAssistant Professor of IHV Epidemiology and Public Health, UMSOM. TRUST clinics are a “safe” place to reach these most vulnerable individuals, hoping to identify and treat HPV damage early and prevent progression to anal cancer. ”

Sexual and gender minorities living with HIV bear the greatest burden of anal cancer, with an 80-fold higher risk than the general population. Despite the high prevalence of HIV in sub-Saharan Africa, anal cancer screening and treatment are not available. therefore, influence This study will provide care for people living with HIV who are at the highest risk of anal cancer in Nigeria.

“Ciheb will continue to strengthen research capacity and infrastructure in these regions to meet the cancer challenges across sub-Saharan Africa, while contributing to evidence that integrates prevention, early detection and diagnosis, and treatment. We aim to accelerate the integration of cancer control interventions based on Dr. Charurat said.

Mark T. Gladwin, MD, said John Z. and Akiko K. Bowers Distinguished Professor and Dean of UMSOM, Vice Presidents for Medical Affairs at the University of Maryland Baltimore. “Countries in sub-Saharan Africa face a double burden of disease. Cancer incidence is rising rapidly, along with continued morbidity and mortality from infectious diseases such as HIV. It is estimated that by 2030, 75% of all cancer deaths will occur in low- to middle-income countries. B SMART When impact, Those designed to result in evidence-based interventions are urgent. ”

About Human Virology Research Institute

Founded in 1996 as a partnership between the State of Maryland, the City of Baltimore, the University of Maryland System, and the University of Maryland Health System, IHV is the Institute of Medicine at the University of Maryland School of Medicine and is the most premier global laboratory in all of virology. recognized and world-renowned experts. IHV combines the fields of basic, epidemiological and clinical research to accelerate the diagnosis and discovery of treatments for a wide range of chronic and deadly viruses and immune disorders, including HIV, the virus that causes AIDS. are making a concerted effort to For more information, see: ihv.org Follow us on Twitter @IHVmaryland.

About the Center for Global Health, Education and Biosecurity

Founded in 2016, the Center for Global Health, Education, and Biosecurity is an international research center created within the University of Maryland School of Medicine by the Institute for Human Virology. Ciheb’s mission is to improve people’s health, protect communities from health-related threats, and promote health equity around the world. Ciheb currently runs 16 programs and training grants in sub-Saharan Africa. For more information, www.ciheb.ihv.org Follow us on Twitter @CIHEB_UMB

About the University of Maryland School of Medicine

The three-century University of Maryland School of Medicine was chartered in 1807 as the first public medical school in the United States. The world’s fastest growing premier biomedical research, with a faculty of over 3,000 physicians, scientists and allied health professionals, including 46 academic departments, centers, laboratories, programs and members It continues today as one of the companies. He holds honorary doctorates from the National Academy of Medicine and the National Academy of Sciences, and is a two-time recipient of the Albert E. Lasker Award for Medical Research. With an operating budget of more than $1.3 billion, the School of Medicine works closely with the University of Maryland Medical Center and the health system to provide research-intensive, academic, and clinical-based care to approximately 2 million patients each year. I’m here. The medical school has about $600 million in extramural funding, and most of its departments rank highly among all medical schools nationwide for research funding. As one of the seven colleges that make up the University of Maryland-Baltimore campus, the School of Medicine has approximately 9,000 faculty and staff, including 2,500 students, trainees, residents and fellows. The combined annual budget of the medical school and healthcare system (the “University of Maryland School of Medicine”) exceeds $6 billion and has an economic impact of nearly $20 billion on the state and community.medical schools ranked as 8th highest #1 among public medical colleges for research productivity (according to the Association of Medical Colleges profile), it is an innovator in translational medicine with 606 active patents and 52 start-ups.. in the latest US News & World Report Ranking of Best Medical Schools 2021, UM School of Medicine 9th place among 92 public medical schools Top 15% in the US (#27) out of 192 total public and private US medical school. The School of Medicine operates locally, nationally and globally, with research and treatment facilities in 36 countries around the world.visit medschool.umaryland.edu

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